| AL Injuries | | |
| Baltimore Orioles |
| Fielders | Pos. | Date | Details | Status | Injury |
| Brian Roberts | 2B | 02/23/2010 | is questionable for the start of the season | Questionable | herniated disc in lower back |
| Pitcher | Pos. | Date | Details | Status | Injury |
| No significant injuries |
| |
| Boston Red Sox |
| Fielders | Pos. | Date | Details | Status | Injury |
| No significant injuries |
| Pitcher | Pos. | Date | Details | Status | Injury |
| No significant injuries |
| |
| Chicago White Sox |
| Fielders | Pos. | Date | Details | Status | Injury |
| No significant injuries |
| Pitcher | Pos. | Date | Details | Status | Injury |
| No significant injuries |
| |
| Cleveland Indians |
| Fielders | Pos. | Date | Details | Status | Injury |
| No significant injuries |
| Pitcher | Pos. | Date | Details | Status | Injury |
| Anthony Reyes | SP | 02/24/2010 | is on the 60-day disabled list | Out | right elbow surgery |
| |
| Detroit Tigers |
| Fielders | Pos. | Date | Details | Status | Injury |
| No significant injuries |
| Pitcher | Pos. | Date | Details | Status | Injury |
| No significant injuries |
| |
| Kansas City Royals |
| Fielders | Pos. | Date | Details | Status | Injury |
| Mike Aviles | SS | 02/09/2010 | is questionable for the start of the season | Questionable | right elbow surgery |
| Alex Gordon | 3B | 03/07/2010 | is questionable for the start of the season | Questionable | broken right thumb |
| Pitcher | Pos. | Date | Details | Status | Injury |
| Henry Barrera | RP | 03/03/2010 | is on the 60-day disabled list | Out | right elbow surgery |
| |
| LA Angels of Anaheim |
| Fielders | Pos. | Date | Details | Status | Injury |
| No significant injuries |
| Pitcher | Pos. | Date | Details | Status | Injury |
| Scot Shields | RP | 02/23/2010 | is questionable for the start of the season | Questionable | left knee surgery |
| |
| Minnesota Twins |
| Fielders | Pos. | Date | Details | Status | Injury |
| No significant injuries |
| Pitcher | Pos. | Date | Details | Status | Injury |
| Joe Nathan | RP | 03/09/2010 | is questionable for the start of the season | Questionable | torn ligament in right elbow |
| |
| New York Yankees |
| Fielders | Pos. | Date | Details | Status | Injury |
| No significant injuries |
| Pitcher | Pos. | Date | Details | Status | Injury |
| No significant injuries |
| |
| Oakland Athletics |
| Fielders | Pos. | Date | Details | Status | Injury |
| No significant injuries |
| Pitcher | Pos. | Date | Details | Status | Injury |
| Josh Outman | SP | 02/09/2010 | is out indefinitely | Out | left elbow surgery |
| |
| Seattle Mariners |
| Fielders | Pos. | Date | Details | Status | Injury |
| No significant injuries |
| Pitcher | Pos. | Date | Details | Status | Injury |
| Ryan Feierabend | SP | 02/09/2010 | is expected to miss the start of the season | Out | left elbow surgery |
| |
| Tampa Bay Rays |
| Fielders | Pos. | Date | Details | Status | Injury |
| No significant injuries |
| Pitcher | Pos. | Date | Details | Status | Injury |
| No significant injuries |
| |
| Texas Rangers |
| Fielders | Pos. | Date | Details | Status | Injury |
| No significant injuries |
| Pitcher | Pos. | Date | Details | Status | Injury |
| Eric Hurley | SP | 02/09/2010 | is expected to miss the start of the season | Out | right shoulder surgery |
| |
| Toronto Blue Jays |
| Fielders | Pos. | Date | Details | Status | Injury |
| No significant injuries |
| Pitcher | Pos. | Date | Details | Status | Injury |
| Dirk Hayhurst | RP | 02/21/2010 | is on the 60-day disabled list | Out | right shoulder surgery |
| Jesse Litsch | SP | 02/19/2010 | is on the 60-day disabled list | Out | right elbow surgery |
| Dustin McGowan | SP | 02/09/2010 | is questionable for the start of the season | Questionable | right shoulder surgery |
| Scott Richmond | SP | 03/04/2010 | is on the 60-day disabled list | Out | right shoulder impingement |
| |
| |
Recent updates in red.
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