| Player | Previous Rank |
| 1. Rafael Nadal (ESP) | 1 |
| Needs U.S. Open to complete career Grand Slam. |
| 2. Roger Federer (SUI) | 2 |
| Has failed to reach semis at last two majors. |
| 3. Andy Murray (GBR) | 3 |
| Could come out on top in New York. |
| 4. Novak Djokovic (SRB) | 4 |
| Will he ever win another major? |
| 5. Tomas Berdych (CZE) | 6 |
| Has reached at least the semis in last two Slams. |
| 6. Robin Soderling (SWE) | 5 |
| Free-swingin' Swede. |
| 7. Andy Roddick (USA) | 7 |
| A contender in Flushing? |
| 8. Fernando Verdasco (ESP) | 8 |
| Quiet lately. |
| 9. Nikolay Davydenko (RUS) | 9 |
| Is his best tennis in the rear-view mirror? |
| 10. Sam Querrey (USA) | 10 |
| No. 10, for now. |