| Player | Previous Rank |
|---|
| 1. Serena Williams (USA) | 1 |
| Still recovering from foot surgery. |
| 2. Kim Clijsters (BEL) | 2 |
| The favorite in Flushing? |
| 3. Caroline Wozniacki (DEN) | 5 |
| Top seed at U.S. Open. |
| 4. Justine Henin (BEL) | 3 |
| Elbow injury has her out until next season. |
| 5. Venus Williams (USA) | 4 |
| Hasn't played in a while. |
| 6. Jelena Jankovic (SRB) | 6 |
| Does she have a shot in New York? |
| 7. Elena Dementieva (RUS) | 7 |
| Still seeking a major title. |
| 8. Victoria Azarenka (BLR) | 10 |
| Can she finally break through? |
| 9. Francesca Schiavone (ITA) | 8 |
| Why is she still on here? |
| 10. Samantha Stosur (AUS) | 9 |
| Not the same since losing in French Open final. |
